Advantage® II flea treatment for cats and dogs

Advantage® II is a comprehensive treatment that works quickly and starts killing fleas on your cat or dog within 12 hours. It's waterproof after 24 hours and lasts 30 days. This convenient monthly topical solution kills fleas through contact so they don’t have to bite your pet to die.

Golden retriever and cat sitting on floor

Why choose Advantage® II flea control?

  • green-flea-life-cyle-icon
    Kills and prevents

    Kills fleas, flea eggs and flea larvae to prevent re-infestations.

  • applicator-icon
    Easy-to-apply

    Easier than a flea collar. Goes on in seconds. Apply directly to pet’s skin — no hard-to-swallow pills.

  • green-30days-continuous-icon
    30-day continuous protection

    Apply Advantage® II monthly. Starts killing fleas on your cat or dog in 12 hours, waterproof after 24 hours.

  • no-prescription-needed-icon_3
    No prescription needed

    Available over the counter whenever you need it.

labrador retriever puppy and tabby kitten on a walk outside by a lake with green icons for fast and effective

Advantage® II is fast and effective

Advantage® II flea treatment for cats and dogs goes on in seconds and starts killing fleas within 12 hours. It’s waterproof after 24 hours and lasts up to 30 days.  

Advantage II large dog and Advantage II large cat product boxes and topical flea treatment applicator

Find the right Advantage® II option for your pet and your lifestyle

Advantage® II comes in different dosage sizes and package quantities to match the unique needs of your pet and your lifestyle. Dosages are determined by your pet's weight so you get the right amount of protection for their size.


Advantage® II for Cats >

Advantage® II for Dogs >

Fight the misery of biting fleas — protect your pet with Advantage® II today.

Advantage House and Yard product collection for flea control

Advantage® helps control fleas indoors and out

Fleas can infest your entire household: couches, carpets, you name it. Fight fleas from fur to fence™ by treating your pet, home and yard with our full line of Advantage® products. 


View all products and get coupon >

 a man holding a ferret in his hand

Advantage® II flea control for ferrets

Ferrets get fleas too. Advantage® II offers a once-a-month topical flea prevention and treatment for ferrets 10 weeks and older and weighing 1 pound or more.


Find a retailer >

Advantage, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.

PM-US-22-2243

Date of review November 2022

© 2022 Elanco or its affiliates